None.

Here we draw an image that has been cropped by 100 pixels on every side. We assume the image is bigger than 200x200.

To do this we use a clip region.

[C#]

using (Image image = Bitmap.FromFile(Server.MapPath("rez/felix-tchverkin-7pkN83wDZwY-unsplash.jpg"))) {
  Size inset = new Size(100, 100);
  using (Bitmap bm = new Bitmap(image.Size)) {
    using (Graphics graphics = Graphics.FromImage(bm)) {
      RectangleF rect = bm.Bounds;
      rect.Inflate(-inset);
      graphics.Clip = new Region(rect);
      graphics.DrawImage(image, bm.Bounds);
    }
    bm.Save(Server.MapPath("IG8_Graphics_Clip.png"));
  }
}

felix-tchverkin-7pkN83wDZwY-unsplash.jpg

IG8_Graphics_Clip.png